| When | Visitor | Home | Field | Score |
|---|---|---|---|---|
| Mon, Apr 28 @ 9:00 PM | Astros | Padres | 4 | L 10-18 |
| Wed, Apr 30 @ 6:00 PM | Astros | Nationals | 3 | (cancelled) |
| Mon, May 05 @ 7:00 PM | Diamondbacks | Astros | 3 | W 9-17 |
| Wed, May 07 @ 9:00 PM | Phillies | Astros | 3 | (cancelled) |
| Mon, May 12 @ 6:00 PM | Astros | Mets | 4 | (cancelled) |
| Wed, May 14 @ 7:00 PM | Cardinals | Astros | 4 | L 21-10 |
| Mon, May 19 @ 8:00 PM | Astros | Reds | 4 | W 21-11 |
| Mon, May 19 @ 9:00 PM | Phillies | Astros | 4 | L 19-11 |
| Wed, May 21 @ 8:00 PM | Dodgers | Astros | 3 | L 16-13 |
| Wed, May 28 @ 7:00 PM | Astros | Red Sox | 3 | W 11-6 |
| Mon, Jun 02 @ 6:00 PM | Astros | Angels | 4 | L 11-18 |
| Wed, Jun 04 @ 8:00 PM | White Sox | Astros | 3 | L 14-13 |
| Mon, Jun 09 @ 7:00 PM | Rangers | Astros | 3 | L 24-22 |
| Wed, Jun 11 @ 9:00 PM | Athletics | Astros | 3 | L 20-9 |
| Mon, Jun 16 @ 6:00 PM | Astros | Yankees | 3 | W 9-4 |
| Wed, Jun 18 | Astros | BYE | ||
| Mon, Jun 23 @ 8:00 PM | Astros | Athletics | 4 | W 21-18 |
| Wed, Jun 25 @ 8:00 PM | Angels | Astros | 3 | W 11-15 |
| Mon, Jun 30 @ 6:00 PM | Astros | White Sox | 3 | L 7-10 |
| Wed, Jul 02 @ 6:00 PM | Red Sox | Astros | 4 | W 7-10 |
| Mon, Jul 07 @ 7:00 PM | Astros | Rangers | 4 | (cancelled) |
| Wed, Jul 09 @ 6:00 PM | Yankees | Astros | 3 | W 8-12 |
| Mon, Jul 14 | Astros | BYE |
