| When | Visitor | Home | Field | Score |
|---|---|---|---|---|
| Mon, Apr 28 @ 9:00 PM | Astros | Padres | 4 | W 10-18 |
| Wed, Apr 30 @ 6:00 PM | Padres | Angels | 4 | (cancelled) |
| Mon, May 05 @ 7:00 PM | White Sox | Padres | 4 | L 13-11 |
| Wed, May 07 @ 8:00 PM | Padres | Athletics | 3 | (cancelled) |
| Mon, May 12 @ 8:00 PM | Padres | Rangers | 4 | (cancelled) |
| Wed, May 14 @ 7:00 PM | Padres | Red Sox | 3 | W 20-4 |
| Mon, May 19 @ 6:00 PM | Yankees | Padres | 3 | L 12-7 |
| Wed, May 21 | Padres | BYE | ||
| Wed, May 28 @ 6:00 PM | Padres | Phillies | 3 | L 14-16 |
| Mon, Jun 02 @ 8:00 PM | Mets | Padres | 4 | W 19-20 |
| Mon, Jun 02 @ 9:00 PM | Padres | Athletics | 3 | L 14-15 |
| Wed, Jun 04 @ 7:00 PM | Padres | Diamondbacks | 4 | L 5-16 |
| Mon, Jun 09 @ 7:00 PM | Nationals | Padres | 4 | W 11-12 |
| Wed, Jun 11 @ 8:00 PM | Padres | Reds | 4 | W 15-9 |
| Mon, Jun 16 @ 7:00 PM | Cardinals | Padres | 4 | L 18-12 |
| Wed, Jun 18 @ 6:00 PM | Padres | Dodgers | 4 | W 8-7 |
| Mon, Jun 23 @ 6:00 PM | Phillies | Padres | 3 | W 12-14 |
| Wed, Jun 25 @ 6:00 PM | Padres | Mets | 3 | L 15-16 |
| Mon, Jun 30 @ 8:00 PM | Reds | Padres | 4 | W 11-18 |
| Wed, Jul 02 @ 9:00 PM | Padres | Nationals | 3 | L 17-20 |
| Mon, Jul 07 @ 6:00 PM | Padres | Cardinals | 3 | (cancelled) |
| Wed, Jul 09 @ 9:00 PM | Dodgers | Padres | 3 | W 4-14 |
| Mon, Jul 14 @ 7:00 PM | Diamondbacks | Padres | 4 | L 15-13 |
